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Simultaneous magnetic resonance and optical elastography acquisitions

Magnetic Resonance Elastography (MRE) with 3D inversion and Optical Elastography (OE) with averaged 1D curve fitting were used to derive complex shear moduli from each imaging modality. [Link]

Demonstration of Concurrent Tensile Testing and Magnetic Resonance Elastography

Figure 1
Figure: Axial images of a central slice for specimen at 0 and 140 % strain and using f = 2.0 kHz. The magnitude image, wave x-motion, y-motion, z-motion, and G stiffness map (shear storage modulus) are displayed from left to right, respectively. The areas within the black dotted lines drawn on the magnitude images represent the masked ROIs used for all image post processing and averaging. Separate ROI masks were constructed for each strain increment to match the changing specimen diameter in response to elongation.

Development of a device for simultaneous tensile testing and MRE.[Link]

Sample interval modulation (SLIM) for simultaneous acquisition of displacement vector

Figure 2
Figure: (Top) Comparison of wave images acquired from conventional and SLIM MRE. (Left) The relation between the displacement projections ux, uy and uz (solid lines) and the onset of the respective MEG (circles).

Concurrent 3D acquisition of diffusion tensor imaging and magnetic resonance elastography displacement data (dMRE)


Comparison of in vivo dMRE results with conventional MRE and diffusion experiments. [Link]

Intra Voxel Phase Dispersion (IVPD) MRE

Single-voxel IVPD-MRE, is based on the intravoxel phase dispersion (IVPD) effect, which represents MRI signal reduction due to dephasing imposed by vibration induced voxel deformation. Lengths of wave structures in MR magnitude image are shortened by a factor of 2 compared to wave lengths in MR phase image. [Link]

Prostate Cancer Diagnosis Using MRE

The purpose of this research is to detect and localize prostate cancer ex vivo using human
prostate samples without pathology fixation or prior radiation therapy.

SLIM-MRE Study on a Mouse Model of Familial Alzheimer's Disease

The goal of the research is to use SLIM-MRE, a fast motion encoding concept developed by our group [link], in order to examine the early diagnostic potential of MRE for Alzheimer’s disease (AD). If MRE was sensitive to early stages of AD, then the technique would qualify as a non-invasive monitor for novel, potential treatments for AD.

  

Examination of Lysed Tissue Samples Using Tabletop MRE

Porcine kidney specimen scanned in axial orientation in a glass capillary.
(a) The magnitude image shows a homogeneous tissue distribution. Compared to the native shear wave image,
(b) waves in the lysed image (c) show a shorter wave length, indicating a decrease in stiffness.